Daniel Levey

About

Work

Yale University
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Assistant Professor

US

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VA Connecticut Healthcare System

US

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Yale University School of Medicine
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Associate Research Scientist

US

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Yale University
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Postdoc

US

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Education

Indiana University School of Medicine
United States of America

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PhD. Major: Medical Neuroscience Minor: Cancer Biology

Publications

The Genetics of Fibromyalgia and its Relationships to Psychiatric and Medical Traits

Summary

preprint

Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing Psychopathology

Summary

preprint

Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses

Published by

Molecular Psychiatry

Summary

journal-article

A contextual genomic perspective on physical activity and its relationship to health, well being and illness

Published by

Nature Genetics

Summary

journal-article

Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes

Summary

preprint

A contextual genomic perspective on physical activity and its relationship to health, well-being and illness

Summary

preprint

Genetics of SSRI Antidepressant Use and Relationship to Psychiatric and Medical Traits

Summary

preprint

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.

Published by

Cell

Summary

journal-article

A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies

Summary

preprint

Genetics of Depression

Published by

Charney and Nestler's Neurobiology of Mental Illness

Summary

book-chapter

Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology

Published by

Psychological Medicine

Summary

journal-article

Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology

Published by

Psychological Medicine

Summary

journal-article

Opioid use disorder and brain health: observational and genetic associations

Summary

preprint

Examining Methylation at the Intersection of Genetic Risk To Alzheimer’s Disease And Alcohol Use Disorder

Published by

Alzheimer's & Dementia

Summary

journal-article

Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction

Published by

Nature Communications

Summary

journal-article

Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses

Summary

preprint

Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis

Published by

Annals of Clinical and Translational Neurology

Summary

journal-article

54712 Bipolar disorder among patients with atopic dermatitis: A case-control study in the All of Us research program

Published by

Journal of the American Academy of Dermatology

Summary

journal-article

Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits

Published by

Molecular Psychiatry

Summary

journal-article

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology

Published by

Nature Human Behaviour

Summary

journal-article

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

Published by

Science

Summary

journal-article

Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD

Published by

Nature Mental Health

Summary

journal-article

Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD

Published by

Nature Mental Health

Summary

journal-article

Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders

Published by

Molecular Psychiatry

Summary

journal-article

Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence

Published by

Nature Human Behaviour

Summary

journal-article

Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populations

Published by

Cell Genomics

Summary

journal-article

Association between psoriasis and obsessive-compulsive disorder: a case-control study in the All of Us research program.

Published by

Archives of dermatological research

Summary

journal-article

Alcohol use and risk of dementia in diverse populations

Summary

preprint

Dissecting the Relationships Between Cannabis Use Disorder and Schizophrenia Using Genome-Wide Approaches

Published by

Biological Psychiatry

Summary

journal-article

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

Published by

Nature genetics

Summary

journal-article

Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing Psychopathology

Summary

preprint

A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra

Summary

preprint

Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression

Published by

Nature Communications

Summary

journal-article

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Published by

Nature Genetics

Summary

journal-article

Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

Summary

preprint

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology

Summary

preprint

Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program

Published by

Archives of Dermatological Research

Summary

journal-article

Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications

Published by

Nature Genetics

Summary

journal-article

Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies

Published by

Molecular Psychiatry

Summary

journal-article

Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration

Published by

Nature Communications

Summary

journal-article

Association between cannabis use and brain imaging phenotypes in UK Biobank: an observational and Mendelian randomization study

Summary

preprint

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses

Published by

Nature Medicine

Summary

journal-article

Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs

Published by

Molecular Psychiatry

Summary

journal-article

Genomewide association study of epiretinal membrane: discovery of significant risk loci in each of three American populations

Summary

preprint

Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology

Published by

Nature Communications

Summary

journal-article

Exploring the genetic overlap between twelve psychiatric disorders

Published by

Nature Genetics

Summary

journal-article

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells

Published by

Nature Communications

Summary

journal-article

Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effects

Published by

Molecular Psychiatry

Summary

journal-article

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci

Published by

Molecular Psychiatry

Summary

journal-article

Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records

Published by

Molecular Psychiatry

Summary

journal-article

Genome-wide association study investigating short and long sleep duration: a cross-population meta-analysis

Summary

preprint

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbidities

Summary

preprint

Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference

Summary

preprint

Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses

Published by

PLOS Medicine

Summary

journal-article

Genome-wide investigation of maximum habitual alcohol intake (MaxAlc) in 247,755 European and African Ancestry U.S. Veterans informs the relationship between habitual alcohol consumption and alcohol use disorder

Summary

preprint

Exploring the genetic overlap between 12 psychiatric disorders

Summary

preprint

Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder

Published by

Molecular Psychiatry

Summary

journal-article

Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records

Summary

preprint

Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits

Published by

Molecular Psychiatry

Summary

journal-article

Impact of moderate alcohol consumption on brain iron and cognition: observational and genetic analyses

Summary

preprint

Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans

Published by

Molecular Psychiatry

Summary

journal-article

Genetic contributions to anxiety disorders: where we are and where we are heading

Published by

Psychological Medicine

Summary

journal-article

Alcohol consumption and telomere length: observational and Mendelian randomization approaches

Summary

other

Genetic variants associated with cross-disorder and disorder-specific risk for psychiatric disorders are enriched at epigenetically active sites in peripheral lymphoid cells

Summary

preprint

Comorbid-phenome prediction and phenotype risk scores enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder

Summary

other

Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs

Published by

Molecular Psychiatry

Summary

journal-article

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions

Published by

Nature Neuroscience

Summary

journal-article

Dissecting Biological Pathways of Psychopathology using Cognitive Genomics

Summary

preprint

Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990-1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006.

Published by

Brain sciences

Summary

journal-article

Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression.

Published by

Human molecular genetics

Summary

journal-article

Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder.

Published by

Psychological medicine

Summary

journal-article

Whole exome sequencing in the UK Biobank reveals risk gene SLC2A1 and biological insights for major depressive disorder

Summary

other

Genome-wide association study and multi-trait analysis of opioid use disorder identifies novel associations in 639,709 individuals of European and African ancestry

Summary

preprint

Dissecting the heterogeneity of posttraumatic stress disorder: differences in polygenic risk, stress exposures, and course of PTSD subtypes.

Published by

Psychological medicine

Summary

journal-article

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

Published by

Nature Genetics

Summary

journal-article

Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality.

Published by

Neurobiology of stress

Summary

journal-article

Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality

Published by

Translational Psychiatry

Summary

journal-article

Complex multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidal behaviors

Summary

preprint

Genome-wide meta-analysis of insomnia in over 2.3 million individuals implicates involvement of specific biological pathways through gene-prioritization

Summary

other

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

Summary

preprint

Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder

Summary

other

Trauma and posttraumatic stress interact with sex-specific risk loci for suicidality and converge on brain extracellular matrix biology and synaptic plasticity

Summary

other

Shared loci of telomere length with brain morphology, and pleiotropy in transcriptomic and epigenomic profiles of brain

Summary

other

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

Published by

Nature Neuroscience

Summary

journal-article

GWAS of Depression Phenotypes in the Million Veteran Program and Meta-analysis in More than 1.2 Million Participants Yields 178 Independent Risk Loci

Summary

other

Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program

Published by

American Journal of Psychiatry

Summary

journal-article

Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs.

Published by

Molecular psychiatry

Summary

journal-article

Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci

Published by

Biological Psychiatry

Summary

journal-article

Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci

Published by

Biological Psychiatry

Summary

journal-article

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

Summary

preprint

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

Published by

bioRxiv

Summary

preprint

Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study

Published by

Depression and Anxiety

Summary

journal-article

Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study

Published by

Depression and Anxiety

Summary

journal-article

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans

Published by

Nature Neuroscience

Summary

journal-article

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans

Published by

Nature Neuroscience

Summary

journal-article

Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs

Published by

Molecular Psychiatry

Summary

journal-article

Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs

Published by

Molecular Psychiatry

Summary

journal-article

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

Summary

other

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

Summary

other

Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs

Published by

Molecular Psychiatry

Summary

journal-article

Genetic associations with suicide attempt severity and genetic overlap with major depression.

Published by

Translational psychiatry

Summary

journal-article

Genetic associations with suicide attempt severity and genetic overlap with major depression

Published by

Translational Psychiatry

Summary

journal-article

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Published by

Nature Communications

Summary

journal-article

Precision medicine for suicidality: from universality to subtypes and personalization.

Published by

Molecular psychiatry

Summary

journal-article

Precision medicine for suicidality: From universality to subtypes and personalization

Published by

Molecular Psychiatry

Summary

journal-article

Mood, stress and longevity: convergence on ANK3.

Published by

Molecular psychiatry

Summary

journal-article

Mood, stress and longevity: Convergence on ANK3

Published by

Molecular Psychiatry

Summary

journal-article

Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment.

Published by

Molecular psychiatry

Summary

journal-article

Towards understanding and predicting suicidality in women: Biomarkers and clinical risk assessment

Published by

Molecular Psychiatry

Summary

journal-article

Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach.

Published by

Molecular psychiatry

Summary

journal-article

Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach

Published by

Molecular Psychiatry

Summary

journal-article

Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions.

Published by

Molecular psychiatry

Summary

journal-article

Psychiatric blood biomarkers: Avoiding jumping to premature negative or positive conclusions

Published by

Molecular Psychiatry

Summary

journal-article

Genetic risk prediction and neurobiological understanding of alcoholism.

Published by

Translational psychiatry

Summary

journal-article

Erratum: Genetic risk prediction and neurobiological understanding of alcoholism (Translational Psychiatry (2014) 4 (e391) DOI:10.1038/tp.2014.29)

Published by

Translational Psychiatry

Summary

journal-article

Genetic risk prediction and neurobiological understanding of alcoholism.

Published by

Translational psychiatry

Summary

journal-article

Genetic risk prediction and neurobiological understanding of alcoholism

Published by

Translational Psychiatry

Summary

journal-article

Discovery and validation of blood biomarkers for suicidality.

Published by

Molecular psychiatry

Summary

journal-article

Discovery and validation of blood biomarkers for suicidality

Published by

Molecular Psychiatry

Summary

journal-article

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.

Published by

Molecular psychiatry

Summary

journal-article

Convergent functional genomics of schizophrenia: From comprehensive understanding to genetic risk prediction

Published by

Molecular Psychiatry

Summary

journal-article